They predispose in particular to medullar and ductal G3 tumors (usually without DCIS component), and BRCA1-associated breast cancers are commonly triple-negative, that is they have no expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). The gene discussed is BRCA1; the disease is ductal breast carcinoma in situ.