LRRK2 and Parkinson disease: To gain insight into the potential relevance of these LRRK2-dependent lipid changes in the CNS of PD subjects, we measured the levels of various GSLs and BMP in CSF from healthy control and PD subjects with or without LRRK2 variants using samples collected from the LRRK2 Cohort Consortium (Supplementary Table 4) [49].