Moreover, the KEGG pathway enrichment and GSEA analysis of RNA-seq data showed that gene sets involved in M2 polarization of tumor-associated macrophages, including the JAK-STAT signaling pathway, were distinctly activated in the circDCP2 overexpression group compared to the empty vector group (Figs. 5A and 7B and Fig. S7A). This evidence concerns the gene SOAT1 and neoplasm.