Conversely, in ABCC10-knockout or ABCC10-knockdown cancer cells, the upregulation of pTBK1, pIRF3, and IFNB1 was further amplified in the presence of both exogenous and endogenous cGAMP (Fig. 5i, j and Supplementary Fig. 6f, g). The gene discussed is ABCC10; the disease is cancer.