MAPT and Alzheimer disease: Both the prefrontal cortex and hippocampus display substantial levels of neurodegeneration and amyloid beta (Aβ) plaque and tau neurofibrillary tangle (NFT) accumulation over the course of Alzheimer’s disease (AD), so it is unsurprising that alongside declarative memory loss, cognitive deficits underlying executive dysfunction are among the most frequently reported symptoms associated with disease progression3,12–15.