For example, researchers have used CRISPR/Cas9 to create an ADTKD-UMOD mouse model and discovered that an endoplasmic reticulum chaperone protein, immunoglobulin heavy chain-binding protein (BiP), is upregulated during the progression of ADTKD-UMOD. The gene discussed is HSPA5; the disease is autosomal dominant medullary cystic kidney disease with or without hyperuricemia.