Although higher concentrations of the compound were required, GIST-R9 and GIST430 cells showed results similar to those of CAY10594-treated GIST-T1 cells; the protein levels of KIT decreased, AKT and STAT5 were dephosphorylated, and pPKD2S876 was not reduced (Fig. 1e; Suppl. This evidence concerns the gene KIT and gastrointestinal stromal tumor.