To evaluate this hypothesis, we treated GIST-T1 cells, which endogenously express a constitutively active KITΔ560–578 mutant (imatinib-sensitive)31with CAY10594 (an inhibitor of PLD activity)32,33 and examined whether PLD inhibition mimicked the inhibition of PKD2 on KIT localisation and growth signalling. This evidence concerns the gene PKD2 and gastrointestinal stromal tumor.