NUAK2 and NUAK1 share roughly 60% sequence identity (Skalka et al, 2024; Molina et al, 2021), and have shared functions in cytoskeletal remodeling, metabolic adaption, proliferation, and EMT—key hallmarks of cancer (Skalka et al, 2024; van de Vis et al, 2021; Namiki et al, 2011). The gene discussed is NUAK2; the disease is cancer.