NUAK2 and central nervous system cancer: Given the critical role of the ECM in regulating glioma cell migration and invasion (Pontes and Mendes, 2023; Schönthal et al, 2023; Wei et al, 2024) and the enrichment of ECM-related DEGs in U251-NUAK2-CR (Fig. 6A), we investigated how modulation of NUAK2 expression affects glioma cell behavior.