Additionally, analysis of the Chinese Glioma Genome Atlas (CGGA) databases (Fig. 1C) and TCGA (Fig. 1D) revealed a correlation between NUAK2 levels and glioma tumor grade, where high-grade gliomas exhibited greater NUAK2 expression than low-grade gliomas (Fig. 1C,D); implying that NUAK2 may play a role in brain tumor malignancy. This evidence concerns the gene NUAK2 and glioma.