Likewise, re-analysis of available LAM-HTGTS data18 (NCBI SRA: PRJNA483469) showed a significant increase in targeting of relapse-associated genes by the RAG–ESC complex compared with the RAG–RSS complex in cells derived from a patient with relapsed ETV6–RUNX1 BCP-ALL (Fig. 5c). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.