RAG1 and acute lymphoblastic leukemia: However, RAGs are aberrantly expressed in most BCP-ALL subtypes28–30 (Extended Data Fig. 1c), and analysis of cDNA from more than 85 patient samples shows that expression of RAG1, but not RAG2, is significantly increased at diagnosis in patients who subsequently relapse (Extended Data Fig. 1d; RAG1: P = 0.0022).