In line with these findings, IPA produced by Lactobacillus plantarum L168 is capable of alleviating intestinal inflammation and tumor growth, which inhibits Saa3-linked cholesterol metabolism in CD8+ T cells through chromatin remodeling to increase the cytotoxic function of tumor-infiltrating CD8+ T cells in CRC [88]. This evidence concerns the gene CD8A and colorectal carcinoma.