It has been reported in the literature that resveratrol can prevent oxidative stress-induced aging and proliferation damage by activating the AMPK/FOXO3 signaling pathway.313 Oleanolic acid induces autophagy and apoptosis in colon cancer cells by modulating the AMPK-mTOR signaling pathway, thereby exerting therapeutic effects against colorectal cancer.314. Here, PRKAA1 is linked to colonic neoplasm.