STAT3 and neoplasm: Persistent STAT3 activation, in particular, suppresses cytotoxic responses and fosters MDSC accumulation, further exacerbating cancer risk.33 Moreover, the dysregulation of microRNAs (miRNAs) in the tumor microenvironment plays a crucial role in modulating immune responses and promoting tumor progression.219 Exosome-mediated lipid metabolic communication also plays a vital role in modulating the tumor microenvironment and promoting digestive system neoplasms.220