Activation of PVN OXT neurons, as well as intranasal OXT, increases parasympathetic activity to the heart, restores autonomic balance, and prevents or mitigates the adverse cardiorespiratory dysregulation that occurs in many diseases with autonomic imbalance, including chronic intermittent hypoxia induced hypertension (Rodriguez et al., 2023), heart failure (Garrott et al., 2017; Dyavanapalli et al., 2020a,b), and myocardial infarction (Schunke et al., 2023). Here, OXT is linked to heart failure.