Present results show for the first time that adults affected by CeD on GFD exhibit significantly increased transcriptional levels of HERV-H-pol, HERV-K-pol, HERV-W-pol, SYN1, SYN2, and HERV-W-env in the peripheral blood as compared with HC of similar age. This evidence concerns the gene SYN2 and cranioectodermal dysplasia.