Whether this retroviral upregulation 1) involves other HERVs, 2) is present also in adults, 3) is linked to TRIM28 and SETDB1 alterations, 4) persists or disappears in patients on GFD, and 5) is more marked in CeD patients with SLD, remain unanswered questions. This evidence concerns the gene TRIM28 and cranioectodermal dysplasia.