SETDB1 and cranioectodermal dysplasia: No significant differences were found between males and females for every variable taken into consideration both in patients and in the control group, pointing to the not relevant role of HERVs and TRIM28/SETDB1 in determining the higher risk of CeD among women, whose origin has been ascribed to genetic, hormonal, and immunological differences between the genders (Lebwohl et al., 2018).