Eight inflammatory cytokines showed potential risk effects, including the effect of genetically determined IL-10 on IBD (OR = 1.088, 95% CI: 1.013, 1.168, P = 0.032), the effect of macrophage inflammatory protein (MIP)-1a on CD (OR = 1.125, 95% CI: 1.022, 1.238, P = 0.016), and the effect of fibroblast growth factor basic on UC (OR = 1.133, 95% CI: 1.001, 1.282, P = 0.032). The gene discussed is IL10; the disease is inflammatory bowel disease.