I-B, bortezomib, curcumin, and fisetin are examples of NF-κB inhibitors that shown significant promise in addressing chemoresistance in cancer treatment. Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 (PGC-1) is a recognized controller of mitochondrial biogenesis and oxidative metabolism, as well as a coactivator involved in transcription. Here, NFKB1 is linked to cancer.