GP6 and chronic kidney disease: Again, platelets from CKD4 and CKD5D ASA patients showed a significantly decreased integrin response upon GPVI stimulation with CRP-XL in comparison with healthy platelets (Supplemental Figure S2), whereas no differences in platelet reactivity between CKD patients and healthy control subjects were found when platelet activation was induced by ADP or TRAP-6 (Supplemental Figure S2).