LCN2 and chronic kidney disease: CKD mice exhibited significantly increased levels of serum creatinine and urea as well as increased levels of kidney fibrosis (Collagen I and αSMA protein), kidney inflammation (Tnfα, Ccl2, IL1β gene expression) and kidney injury (Lipocalin-2 [Lcn2] expression),17 without significant differences between groups without vs with ASA treatment (Supplemental Figure S10).