We recently characterized a subset of PvTAMs in the mouse mammary tumor virus promoter driven polyoma middle T-antigen (MMTV-PyMT) spontaneous murine model of breast cancer that express the lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1+)MHCIIloCD206hi and are polarized by IL-6 within the TME (9, 18). This evidence concerns the gene LYVE1 and breast cancer.