This response was not chemotherapy class-specific as KCL-HO-1i given alongside gemcitabine also delivered a durable control of tumor growth (Figure 3A), which paralleled the observation using genetic inactivation of HO-1 in MMTV-PyMT mice (Figure 1K), suggesting PvTAMs were the therapeutic target of KCL-HO-1i. Here, HMOX1 is linked to neoplasm.