HMOX1 and neoplasm: The biological changes in the TME in response to KCL-HO-1i mirror those observed through genetic inactivation of HO-1 in Hmox1fl/fl mice with Lyve1Cre in the MMTV-PyMT tumor model, affirming PvTAMs as a key biological target of KCL-HO-1i within the TME.