HMOX1 and neoplasm: To investigate whether KCL-HO-1i induced HO-1 expression we injected KCL-HO-1i into non-tumor bearing HO-1Luc/eGFP reporter mice and measured luciferase (Luc) expression using bioluminescence analysis (as a surrogate of HO-1 expression) over a 24 h period (Figure 2G).