For those of normal weight, the hepatitis B pathway, composed of RB1, EP300, PIK3CB, HSPG2 and JAK1 (K = 9), may serve as a key point for effective treatment and prevention (Fig 5C), because chronic infection with hepatitis viruses is a major causative factor for hepatocellular carcinoma [85]. This evidence concerns the gene RB1 and hepatocellular carcinoma.