For example, two common genes, TP53 and PIK3CA, identified in breast adenocarcinoma cohorts from the US, EU and UK, are IntOGen genes shared by all three cohorts (colored by dark purple in Fig 2A), while GATA3 is a known IntOGen gene present in two of the cohorts (colored by light purple). Here, PIK3CA is linked to breast adenocarcinoma.