For instance, deletion of a type 2 diabetes-associated enhancer within the ONECUT1 locus reduced the number of one cut homeobox 1 (ONECUT1)- and pancreatic and duodenal homeobox 1 (PDX1)-positive pancreatic progenitors [18], implicating this element in early beta cell differentiation. Here, PDX1 is linked to type 2 diabetes mellitus.