INS and type 2 diabetes mellitus: Similarly, serum proteomic analyses from the AGES-Reykjavik/AGESII cohort identified several candidate protein predictors of type 2 diabetes (IGF-binding protein 2 [IGFBP2], apolipoprotein M [APOM], inhibin βC chain [INHBC] and growth hormone receptor [GHR]), many of which are implicated in insulin signalling and metabolic stress pathways [25].