Since DMXL2 variants are already implicated in SNHL, aberrant DNA methylation of this gene identified from two independent WGBS studies, along with preliminary qRT-PCR results suggesting altered expression of this gene in MD clusters, implores further investigation of potential implications of DMXL2 gene expression in MD with respect to DNA methylation-driven patient clusters. Here, DMXL2 is linked to sensorineural hearing loss disorder.