Thus, Sgk3-KO mice exhibited protection from glucocorticoid-induced obesity while remaining sensitive to its immunosuppressive effects, as shown by decreased spleen weight, suggesting SGK3 as a potential important target for mitigating glucocorticoid-induced metabolic side effects without affecting glucocorticoid’s immune suppression effects. Here, SGK3 is linked to obesity due to melanocortin 4 receptor deficiency.