For instance, the epidermal-specific deletion of inhibitor of NF-kB kinase 2 (IKK2) or the double knockout of the c-Jun and JunB genes in mice resulted in psoriasis-like phenotypes in a T-cell-independent manner (Pasparakis et al., 2002; Zenz et al., 2005). The gene discussed is JUNB; the disease is psoriasis.