TP53BP2 and gastric cancer: For example, Buti et al. (2020), by constructing a co-culture system of H. pylori with gastric organs, found that its virulence factor, CagA, bound to the Apoptosis stimulating protein of p53-2 (ASPP2) to form a complex ASPP2 induces the remodeling of cell polarity complexes, resulting in the loss of cell polarity and the promotion of epithelial-mesenchymal cell transformation, which affects the development and metastasis of gastric cancer.