SHBG and alcohol dependence: There was no genetic correlation of alcohol dependence with SHBG in females (rg = -0.02, p = 0.70) or males (rg = 0.07, p = 0.18); however, alcohol dependence trended toward positive genetic correlation with BMI-adjusted SHBG in males (rg = 0.12, p = 0.02) but not females (rg = 0.03, p = 0.61) (Table 2).