Genetic variations associated with CDLS have been identified in several genes, including SMC1A, SMC3, RAD21, NIPBL, HDAC8, BRD4, and ANKRD11 (Cochran et al., 2019), with mutations in the NIPBL gene being the most prevalent (Kline et al., 2018). This evidence concerns the gene SMC1A and Cornelia de Lange syndrome.