There was no significant difference in the total IgE or sIgE (medians: total IgE: 461.50 vs. 965.80 kUA/L, p = 0.45; sIgE: 4.63 vs. 11.80 kUA/L, p = 0.20, Supplementary Figures S6B,C), SPT wheal size (4.75 vs. 5 mm, p = 0.71, Supplementary Figure S6D), or atopic history (asthma p = 0.69, allergic rhinitis p = 0.91, atopic dermatitis p = 0.40; Supplementary Figure S7) between participants with and without reactivity to DBPCFC. This evidence concerns the gene IGHE and atopic eczema.