14 psychiatric events suitable for the definition of corticosteroid-induced psychiatric disorders (CIPDs), resolved with corticosteroid dosage reduction; 2 cases of CNS-SLE, required augmentation of immunosuppressive therapy; EEG abnormalities and elevated cerebrospinal fluid (CSF) markers (IL-6, IFN-α) were indicative of CNS-SLE in some cases. The gene discussed is IL6; the disease is psychiatric disorder.