CAV1 and Stroke: In recanalized stroke patients, circulating Caveolin-1 (Cav-1) levels are reduced; however, enhancing Cav-1 expression in endothelial cells in middle cerebral artery occlusion/reperfusion (MCAO/R) injury mice significantly reduces infarct volume, decreases vascular permeability, and mitigates thrombo-inflammation (Zhang X. et al., 2022).