Recent studies further reveal the involvement of circRNAs in inflammatory cell death pathways: circular RNA derived from RIMS1 (circRIMS), previously linked to cancer progression, amplifies NLRP3 inflammasome activity and inflammatory cytokine release by sponging miR-96-5p to activate JAK/STAT1 signaling in CIRI models, while circular RNA from coiled-coil domain-containing 6 (circCCDC6) enhances neuronal injury by suppressing miR-128-3p, leading to TXNIP/NLRP3 pathway activation (Li W. et al., 2023; Wang C. et al., 2023). The gene discussed is NLRP3; the disease is cancer.