PIK3CA and posterior cortical atrophy: The frequent loss of PTEN, a key negative regulator of PI3K/Akt signaling observed in 40%–60% of advanced PCa cases (Jamaspishvili et al., 2018), Cross talk pathway analysis for those hub genes further confirms their role in the Androgen receptor (AR) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways Supplementary Figure S2.