Among these hubs, DPP4 was found to modulate key regulators of this pathway, such as FGF17, PDGFRA, COL4A1 and COL9A2. Our findings suggest that DPP4 inhibition via (Linagliptin) may suppress regulate PI3K/Akt signaling thereby impacting the cell survival and potentially suppressing PCa metastasis. Here, PDGFRA is linked to posterior cortical atrophy.