CDKN2B and cardiac hypertrophy: Accordingly, ANRIL KD has been shown to increase CDKN2B expression.52,53 Additionally, the human lncRNA MIR181A1HG has been shown to be a positive regulator of inflammation in atherosclerosis.57,58 However, no studies have linked ANRIL or MIR181HG specifically to HCM or cardiac hypertrophy.