To test whether SWIFT interacts with a wide number of TFs, we purified FLAG- and HA-tagged SMARCD2 SWIFT domains and incubated these with nuclear extracts from five distinct cell types (cancer cell lines) isolated by ammonium sulfate extraction, followed by HA-immunoprecipitation and mass spectrometry (MS) (Fig. 5B, S8D–E). Here, SMARCD2 is linked to cancer.