Intriguingly, integrating results from genome-scale CRISPR-Cas9-based fitness screens performed across >1000 cancer cell lines, we find that AML cell lines exhibit among the highest co-dependency scores on both PU.1 and SMARCD2, suggesting the possibility that the interaction between PU.1 and SMARCD2 is necessary for oncogenic transcriptional functions in these cells (Fig. 4A, S7A). The gene discussed is SMARCD2; the disease is acute myeloid leukemia.