We next sought to determine whether alteration of the SMARCD2 SWIFT domain-PU.1 interaction is necessary to support the chromatin occupancy, gene regulatory and proliferative signatures of human cancers dependent on the PU.1 transcription factor as a way to probe the concept that TF interactions with this domain may be required for transcription factor-’addicted’ cancers. This evidence concerns the gene SMARCD2 and cancer.