The complexity of MYC and MYCN’s functions as transcriptional regulators mean it is challenging to connect MYC/MYCN binding and MYC/MYCN activity directly, however, our evaluation of data from NB samples appears more reflective of the positive correlation of MYC activity and HNRNPH1 expression seen in AML. This evidence concerns the gene HNRNPH1 and acute myeloid leukemia.