These results suggest that mutations affecting HNRNPH1, as reported in rare neurodevelopmental disorders (12–14) may not disrupt all EIF4G1 protein expression and thus its function, but it may favor the expression of a non-canonical protein isoform of EIF4G1 that lack residues present in the N-terminus of the full length protein and that are adjacent to the PABP binding domain (Supplementary Figure S5). This evidence concerns the gene PABPC1 and neurodevelopmental disorder.