There are no reports of other cancers harboring similar recurrent mutations, however, as recent studies have suggested that the levels of the HNRNPF/H proteins can contribute to tumorigenesis (19), we next examined whether the levels of HNRNPH1 expression could promote alterations in the relative expression of TCF3-exon 18a or TCF3-exon 18b containing transcript variants across tumor types. Here, TCF3 is linked to cancer.