MYC and neoplasm: This study also associated these findings to the observation that in many tumor types, including prostate, ovarian, and lung cancer, HRAS-exon 5 inclusion negatively correlates with a measure of MYC transcriptional activity, and that MYC activity also negatively correlates with HNRNPH1 gene expression, but positively correlates with the expression of HNRNPF. In contrast, acute myeloid leukemia samples show a converse relationship, that is, a positive correlation of MYC activity with HNRNPH1 gene expression, but a negative correlation with the expression of HNRNPF.