These observations could reflect the neural crest origin of NB but prompted by an examination of correlations between MYC activity (defined by a MYC hallmark enrichment score) and HNRNPH1 and HNRNPF expression in different tumor types reported by Chen et al., (19), we evaluated whether the prevalence of MYCN amplification in NB could also be a contributory factor. The gene discussed is MYCN; the disease is neoplasm.