TP53 and hepatocellular carcinoma: For example, HCC with CTNNB1 mutation was characterized by large size, well-differentiation, cholestasis, microtrabecular and pseudoglandular patterns, and lack of inflammatory infiltration; at the same time, TP53 mutated HCC exhibited features such as compact and poor-differentiated tumors, multinuclear and polymorphous cells, macrovascular and microvascular invasion (10).