Somatic mutations in the TERT promoter (observed in 44% of HCC and encoding for the catalytic subunit of telomerase), TP53 (31%, regulating the cell cycle), CTNNB1 (27%, encoding β-catenin, the Wnt pathway oncogene) and ALB (13%, encoding albumin) were most common (8). The gene discussed is TERT; the disease is hepatocellular carcinoma.