In vitro studies have shown that high expression of SLFN11 can significantly enhance the sensitivity of CRC cells to irinotecan’s active metabolite SN-38, manifested by strong anti-proliferative effects, cell apoptosis and cell cycle arrest, which directly confirms that SLFN11 plays an indispensable role in the DNA damage response pathway induced by irinotecan (17). Here, SLFN11 is linked to colorectal carcinoma.