In summary, SLFN11 is a key dynamic regulator of SCLC sensitivity to DNA-damaging drugs, and PARP1 and ETS family transcription factor EHF regulate SLFN11 expression: PARP1 knockdown reduces SLFN11, while EHF is positively correlated with SLFN11 in SCLC and regulates its expression (knockdown of EHF reduces SLFN11). The gene discussed is PARP1; the disease is small cell lung carcinoma.