AKT1 and nonpapillary renal cell carcinoma: It is worth noting that studies have shown that in ccRCC, chemokines such as CXCL13 (whose receptor CXCR5 is strongly positively correlated with SLFN11) can promote tumor progression by binding to CXCR5 to activate the PI3K/AKT/mTOR pathway, and high expression of CXCR3/4/5/6 is associated with poor overall survival (OS) of patients (70, 71).