In summary, SLFN11 is a key dynamic regulator of SCLC sensitivity to DNA-damaging drugs, and PARP1 and ETS family transcription factor EHF regulate SLFN11 expression: PARP1 knockdown reduces SLFN11, while EHF is positively correlated with SLFN11 in SCLC and regulates its expression (knockdown of EHF reduces SLFN11). Here, SLFN11 is linked to small cell lung carcinoma.