Workup revealed elevated C-reactive protein (35.32 mg/L), rheumatoid factor (20.70 IU/mL), anti-streptolysin O (207.00 IU/mL), antinuclear antibody (1:80), Ro52 antibody (positivity), human immunodeficiency virus (HIV) antibody (positivity), syphilis with serum toluidine red unheated serum test (TRUST) (1:2), and anti-Treponema pallidum-specific antibodies (positivity, 245.50 S/CO). The gene discussed is CRP; the disease is syphilis.