Our study shows that LY96 and TMEM140 genes are expected to be shared key biomarkers for the diagnosis and treatment of SLE and PD, which not only provides clinical basis for the diagnosis and treatment of single systemic lupus erythematosus or periodontal disease, but also an ideal diagnosis and treatment indicator for overlapping diseases of the two. The gene discussed is TMEM140; the disease is systemic lupus erythematosus.