CIBERSORT analysis was also conducted on the Periodontal disease data set (GSE16134), The results revealed significant differences between PD and control samples in all cell types, with the exception of T cells CD4 memory resting, NK cells resting, Monocytes, Macrophages M0, Mast cells activated, and Eosinophils (Figure 10B). This evidence concerns the gene CD4 and periodontal disorder.