Using this algorithm, we found that there was increased infiltration of Neutrophils, Dendritic cells activated in SLE samples, and decreased infiltration of T cells CD8 and T cells gamma delta, there was increased infiltration of T cells CD4 memory activated, there was increased infiltration of Plasma cells, T cells CD4 naive and B cells naive in PD samples, and decreased infiltration of B cells memory, T cells CD8, T cells follicular helper, T cells regulatory, NK cells activated, Dendritic cells resting, Macrophages M1, Macrophages M2 and Mast cells resting. Here, CD4 is linked to systemic lupus erythematosus.