GSDMD and Sepsis: Genetic ablation of GSDMD or pharmacological inhibition (e.g., LDC7559) markedly reduces NET generation and prolongs survival in septic mice, identifying the GSDMD-NETs axis as a pivotal regulatory node (5, 6).These mechanistic insights not only deepen our interest in this pathway but also prompt our hypothesis: biomarkers of GSDMD-NETs axis activation may hold significant clinical relevance in sepsis patients with SIC.