Punica granatum peel polysaccharides (PPPs) (96) reduce the psoriasis area and severity index (PASI) and transepidermal water loss (TEWL) by significantly improving psoriasis-like skin lesions, downregulating the expression of Ki67 and CD3, inhibiting the levels of pro-inflammatory cytokines (e. The gene discussed is MKI67; the disease is psoriasis.