(60) confirmed that Angelica gigas polysaccharide (F2 polysaccharide) activated NK-92 cells, augmented their cytotoxic activity toward HCT-116 cells, and promoted the transcription of TNF-α, IFN-γ, NKp44, and Granzyme-B, thereby exerting anti-tumor immune activity through the MAPK and NF-κB signaling cascades. Here, TNF is linked to neoplasm.