PLS3 and Ehlers-Danlos syndrome: Among the 31 women undergoing genetic analysis, a positive result was found in 7 cases (22.6%), thus at least 4.5% of the whole PLAO population was affected by a genetic form of bone fragility (osteogenesis imperfecta (OI), Ehlers Danlos Syndrome (EDS), OI/EDS and Monogenic Juvenile Osteoporosis due to PLS3 mutation were diagnosed in 4, 1, 1 and 1 women, respectively).