There were 34 serum metabolites positively correlated with liver function (ALT, AST), blood lipids (TG, TC, HDL, LDL) and obesity index (lipid weight, body weight, liver weight), and negatively correlated with liver index, which meat that the levels of these metabolites may increase with the increase of obesity and disease risk. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.