Results: We observed a significant disparity in immune cell profiles between patients with RA and HC, notably a reduced frequency of CD27+IgD+ unswitched memory B (mB) cells in patients with RA (p-value < 0.01), with the disease RA being the primary and only significant factor explaining up to 17.9% of the variance of these cells. The gene discussed is CD27; the disease is rheumatoid arthritis.