The first model, including both RA patients and HC, revealed that RA was the only significant predictor of unswitched mB cell frequency (CD45+ parent population: β = −0.752, p  < 0.01; B cell parent population: β = −0.365, p  < 0.05), independent of other covariates (WHR, creatinine, sleep). The gene discussed is PTPRC; the disease is rheumatoid arthritis.