To test whether the TRIM37- and TP53-independent mechanism of sensitivity contributes to anti-tumor activity of RP-1664 in vivo, we engrafted immunodeficient mice with parental CHP134 cells, alongside a TRIM37-KO clone (different than the one used in our in vitro studies but showing the same RP-1664 sensitivity - Extended Data Figure 4A) and a TP53-KO clone. The gene discussed is TP53; the disease is neoplasm.