TP53 and neoplasm: We confirmed that the resulting tumors maintained the desired TRIM37 and p53 status (Extended Data Figure 4B) and treated tumor-bearing mice with either blank chow or 300ppm RP-1664 chow, which in this model led to a daily free plasma RP-1664 concentration of ≤100nM on average, consistent with centriole amplification (Extended Data Figure 4C).