To test this hypothesis, we generated TRIM37- and TP53-CRISPR/Cas9 KO clones in the neuroblastoma cell lines CHP134 and CHP212 (Figure 3C,D) – as well as a clone of CHP134, referred to as TRIM37-low, that retains reduced TRIM37 expression due to residual wild-type alleles (Figure 3C; Extended Data Figure 2C). The gene discussed is TRIM37; the disease is neuroblastoma.