Our analysis revealed that genetic variants in the human orthologs of dmd-5 (DMRTA2 and DMRTB1) and irx-1 (Iroquois homeobox (IRX) protein family genes (IRX1–6)) were associated with metabolic traits, including body weight, cardiovascular disease, and type 2 diabetes (Fig. 4e). Here, IRX1 is linked to cardiovascular disorder.