Chemokine signaling pathways, particularly the CXCL12/CXCR4 axis, were prominently enriched and represent [24, 25] master regulators of breast cancer tumorigenesis, controlling tumor cell proliferation, motility, and metastasis to target organs while affecting both immune and stromal cells to create tumor-supporting microenvironments. This evidence concerns the gene CXCR4 and breast carcinoma.