Additionally, this mode was related to high blood pressure in PheWAS, consistent with hypertension and cerebrovascular disease in DiaWAS, as well as blood and cardiovascular-related medications in MedWAS (e.g., B01A – Antithrombotic Agents, C08C – Selective Calcium Channel Blockers with mainly Vascular Effects, C09A – ACE Inhibitors, C10A – Lipid Modifying Agents) – showing convergence of findings across three separate analyses and data sources. Here, ACE is linked to cerebrovascular disorder.