Fer-1 has also been found to inhibit ROS/RNS, attenuating rotenone-induced α-synuclein aggregation in dopaminergic SH-SY5Y cells (Kabiraj et al., 2015), thereby reversing MPTP-triggered behavioral deficits in a mouse model of PD and protecting the neurons (Do Van et al., 2016). Here, SNCA is linked to Parkinson disease.