APOE and Alzheimer disease: This supports the hypothesis that “APOE4 mainly accelerates AD progression by enhancing the pathological effect of Aβ.” At the same time, the independent effect of APOE4 in the Aβ- group (such as 18 DFC differential connections) suggests that it may pre - disrupt the dynamic balance of brain networks through other pathways (such as lipid metabolism abnormalities), providing imaging evidence for “APOE4 being an independent risk factor for AD.