A 27‐year‐old male diagnosed with CF (homozygous for F508del CFTR mutation) was admitted to hospital with 5 days of progressive peripheral weakness, 3 days of peripheral paraesthesia and a 1‐day history of intermittent diplopia, with increasing difficulty performing airway clearance, occurring two weeks following an unidentified upper respiratory tract infection (URTI). Here, CFTR is linked to cystic fibrosis.