This receptor plays an important role in lymphocyte development and can promote cell survival through activation of the JAK/STAT signaling pathway.28 In a mouse model with a chronic viral infection, PD-1 blockade led to increased IL7R expression and IL-7 signaling, which in term was associated with transient reinvigoration of exhausted CD8+ T cells.29 The literature for this gene’s relation to RCC is relatively sparse, with increased proliferation of tumor-infiltrating lymphocytes observed with IL-7 treatment.30 Here, CD8A is linked to renal cell carcinoma.