The knockout of Sprr1a in mice can improve cardiac dysfunction after myocardial infarction (Kawaguchi et al., 2023), and the expression of Sprr1a in colorectal cancer tissues is significantly increased, which may be used as a potential biomarker for the prognosis of colon cancer (Deng et al., 2020). Here, SPRR1A is linked to colonic neoplasm.